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KMID : 1024320210110010009
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Journal of the Korean Dysphagia Society
2021 Volume.11 No. 1 p.9 ~ p.14
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Novel Animal Model of Oral Dysphagia Following Hemiglossectomy
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Kim Min-Ji
Ho Minh Tri
Kim Jeong-Mi
Choi Mi-Eun
Kim Young-Mo
Choi Jeong-Seok
Kim Ji-Won
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Abstract
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Objective:This study aimed to establish an animal model of oral dysphagia for translational research purposes.
Methods: Four week old C57BL/6 mice were randomized to a surgical partial glossectomy group (horizontal resection, n=13 vs. vertical resection, n=15) and a nonsurgical group (control, n=7). The survival rate, mouse weight, amount of food, and water consumption were compared. Comparisons were made using a Kruskall Wallis test, and survival was analyzed using Kaplan-Meier method.
Results: Eleven of the 13 (84.6%) horizontal resection animals and 11 of the 15 (73.3%) vertical resection animals survived to the study endpoint. Compared to the non-surgical control mice, the mice that had undergone a horizontal and vertical resection had a significantly lower mean body weight (P=0.05) during experimental day (ED) 5, with the greatest dysphagia observed in ED 2. The horizontal resection-type mice showed greater mean body weight loss and food consumption in the early stages of the experiment than the vertical resection-type mice. In contrast, the horizontal resection-type mice showed greater body weight gain and food consumption in the late stages of the experiment.
Conclusion: This study provides novel evidence that the proper timing for an animal model of oral dysphagia was within ED 5; severe dysphagia was observed in ED 2. The horizontal-type partial glossectomy had a better survival rate than the vertical-type model. Furthermore, the prolonged dysphagia model mimics the vertical resection-type mice.
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KEYWORD
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Animal model, Dysphagia, Oral
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